Article

HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data

2023-07-15

Abstract excerpt

Multi-region DNA sequencing of primary tumors and metastases from individual patients helps identify somatic aberrations driving cancer development. However, most methods to infer copy-number aberrations (CNAs) analyze individual samples. We introduce HATCHet2 to identify haplotype- and clone-specific CNAs simultaneously from multiple bulk samples. HATCHet2 introduces a novel statistic, the mirrored haplotype B-al...

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Literature Corpus work: 6751ebb6-4f95-58e5-9cf7-dab54828f401
DOI: 10.1101/2023.07.13.548855

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