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MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

14 Nov 2022

Abstract excerpt

Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplotype-specific somatic copy-number alterations from single-cell or bulk data. MEDICC2 eschews simplifications such as the...

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PMID: 36376909
DOI: 10.1186/s13059-022-02794-9

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