Article

Inferring allele-specific copy number aberrations and tumor phylogeography from spatially resolved transcriptomics

2024-03-13

Abstract excerpt

A key challenge in cancer research is to reconstruct the somatic evolution within a tumor over time and across space. Spatially resolved transcriptomics (SRT) measures gene expression at thousands of spatial locations in a tumor, but does not directly reveal genetic aberrations. We introduce CalicoST, an algorithm to simultaneously infer allele-specific copy number aberrations (CNAs) and a spatial model of tumor e...

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Literature Corpus work: 6f67cf3f-c4aa-5a07-bbd5-53ec1589de6e
DOI: 10.1101/2024.03.09.584244

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