Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data

21 May 2024

Abstract excerpt

Bulk DNA sequencing of multiple samples from the same tumor is becoming common, yet most methods to infer copy-number aberrations (CNAs) from this data analyze individual samples independently. We introduce HATCHet2, an algorithm to identify haplotype- and clone-specific CNAs simultaneously from multiple bulk samples. HATCHet2 extends the earlier HATCHet method by improving identification of focal CNAs and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38773520
DOI: 10.1186/s13059-024-03267-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing dataPMID 38773520Read ↗

HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing dataSemantic proximity Read ↗

Accurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing dataSemantic proximity Read ↗

Accurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing data.Semantic proximity Read ↗

Haplotype-enhanced inference of somatic copy number profiles from single-cell transcriptomesSemantic proximity Read ↗

Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL.Semantic proximity Read ↗

Characterizing the allele- and haplotype-specific copy number landscape of cancer genomes at single-cell resolution with CHISELSemantic proximity Read ↗

Reconstruction of clone- and haplotype-specific cancer genome karyotypes from bulk tumor samplesSemantic proximity Read ↗

Patchwork: allele-specific copy number analysis of whole-genome sequenced tumor tissue.Semantic proximity Read ↗

CloneCNA: detecting subclonal somatic copy number alterations in heterogeneous tumor samples from whole-exome sequencing data.Semantic proximity Read ↗

A Bayesian method to cluster single-cell RNA sequencing data using Copy Number AlterationsSemantic proximity Read ↗

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolutionSemantic proximity Read ↗

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.