Article

Reconstruction of clone- and haplotype-specific cancer genome karyotypes from bulk tumor samples

2019-02-25

Abstract excerpt

Many cancer genomes are extensively rearranged with highly aberrant chromosomal karyotypes. These genome rearrangements, or structural variants, can be detected in tumor DNA sequencing data by abnormal mapping of se-quence reads to the reference genome. However, nearly all cancer sequencing to date is of bulk tumor samples which consist of a heterogeneous mixture of normal cells and subpopulations of cancers cells...

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Literature Corpus work: 8caf0791-c381-540c-824b-f75def3c35e6
DOI: 10.1101/560839

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