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Article

Accurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing data.

Nature communications - 2 Sept 2020

Zaccaria Simone, Raphael Benjamin J

Abstract excerpt

Copy-number aberrations (CNAs) and whole-genome duplications (WGDs) are frequent somatic mutations in cancer but their quantification from DNA sequencing of bulk tumor samples is challenging. Standard methods for CNA inference analyze tumor samples individually; however, DNA sequencing of multiple samples from a cancer patient has recently become more common. We introduce HATCHet (Holistic Allele-specific Tumor...

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Identifiers

PMID: 32879317
DOI: 10.1038/s41467-020-17967-y
PMCID: PMC7468132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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