Article

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

2022-01-01

Abstract excerpt

Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplotype-specific somatic copy-number alterations from single-cell or bulk data. MEDICC2 eschews simplifications such as the infini...

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Literature Corpus work: 90f59fcd-0441-59de-ac10-6234547a2f1e
DOI: 10.17169/refubium-44917

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