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Humanized Caffeine-Inducible Systems for Controlling Cellular Functions

2025-06-13

Abstract excerpt

Current cell therapies are limited by the lack of tools for controlling gene expression using humanized systems responsive to non-toxic stimuli. Starting from nanobodies that homodimerize in response to caffeine, we computationally designed inducible heterodimers and humanized the best-performing pairs. We used the resulting caffeine-inducible domains in engineered cytokine receptors for caffeine-inducible STAT3 s...

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Literature Corpus work
9e9c102a-dac8-5255-8c1a-e8b3c12c266d
DOI
10.1101/2025.06.13.659463
Open publication

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Humanized Caffeine-Inducible Systems for Controlling Cellular FunctionsDOI 10.1101/2025.06.13.659463
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