Article

Cohesin acts as a transcriptional gatekeeper by restraining pause–release to promote processive elongation

2025-10-01

Abstract excerpt

Cohesin organizes 3D chromatin architecture, including promoter–enhancer loops, yet its loss has surprisingly modest effects on steady-state gene expression. We address this paradox by demonstrating that cohesin acts at different stages of transcription. First, it promotes Pol II promoter recruitment by facilitating enhancer–promoter communication that maintains active promoter chromatin states. Second, it delays...

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Identifiers and source

Literature Corpus work: 430c2e3c-896f-53fc-8fef-2172e1998fae
DOI: 10.1101/2025.09.30.679672

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