Article

RNA-binding proteins activate transcription through defined molecular grammars

2026-05-29

Abstract excerpt

Transcription factors (TFs) regulate gene expression through interactions with DNA, RNA, and proteins. RNA-binding proteins (RBPs) also assemble near regulatory elements and mediate RNA processing, yet their perturbation causes transcriptional defects. Here, we find select RBPs activate transcription through latent activation domains akin to TFs. RBP activators regulate distinct genes and interact with transcripti...

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Literature Corpus work: 55090a70-76e6-55ac-ad6e-d631f0edd710
DOI: 10.64898/2026.05.29.728737

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