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Article

The strength of acidic activation domains correlates with their affinity for both transcriptional and non-transcriptional proteins.

Journal of molecular biology - 1 Sept 2000

Melcher K

Abstract excerpt

Activation domains (ADs) appear to work by making specific protein-protein contacts with the transcriptional machinery. However, ADs show no apparent sequence conservation, they can be functionally replaced by a number of random peptides and unrelated proteins, and their function does not depend on sustaining a complex tertiary structure. To gain a broader perspective on the nature of interactions between acidic...

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Identifiers

PMID: 10966808
DOI: 10.1006/jmbi.2000.4034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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