Article
The strength of acidic activation domains correlates with their affinity for both transcriptional and non-transcriptional proteins.
Journal of molecular biology - 1 Sept 2000
Melcher K
Abstract excerpt
Activation domains (ADs) appear to work by making specific protein-protein contacts with the transcriptional machinery. However, ADs show no apparent sequence conservation, they can be functionally replaced by a number of random peptides and unrelated proteins, and their function does not depend on sustaining a complex tertiary structure. To gain a broader perspective on the nature of interactions between acidic...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Calibration
- DNA-Binding Proteins
- Fungal Proteins
- Herpes Simplex Virus Protein Vmw65
- Humans
- Isoelectric Point
- Models, Biological
- Molecular Sequence Data
- Muramidase
- Mutation
- Proteasome Endopeptidase Complex