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Article

Cognitive resilience to Alzheimer's disease characterized by cell-type abundance.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2024

O'Neill Nicholas, Stein Thor D, Olayinka Oluwatosin A, Empawi Jenny A, Hu Junming, Tong Tong, Zhang Xiaoling, Farrer Lindsay A

Abstract excerpt

INTRODUCTION: The molecular basis of cognitive resilience (CR) among pathologically confirmed Alzheimer's disease (AD) cases is not well understood. METHODS: Abundance of 13 cell types and neuronal subtypes in brain bulk RNA-seq data from the anterior caudate, dorsolateral prefrontal cortex (DLPFC), and posterior cingulate cortex (PCC) obtained from 434 AD cases, 318 cognitively resilient AD cases, and 188...

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Identifiers

PMID: 39262221
DOI: 10.1002/alz.14187
PMCID: PMC12060125

Genes

PVALB
TMEM106B
RORB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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