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Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing

17 Apr 2018

Abstract excerpt

BACKGROUND: Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. Aberrant AS plays an important role in regulating various diseases, including cancers. METHODS: In this study, we integrated AS events...

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PMID: 29665865
DOI: 10.1186/s13073-018-0538-1

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