Article
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Nature medicine - 1 Apr 2015
Chen Chun-Wei, Koche Richard P, Sinha Amit U, Deshpande Aniruddha J, Zhu Nan, Eng Rowena, Doench John G, Xu Haiming, Chu Scott H, Qi Jun, Wang Xi, Delaney Christopher, Bernt Kathrin M, Root David E, Hahn William C, Bradner James E, Armstrong Scott A
Abstract excerpt
Rearrangements of MLL (encoding lysine-specific methyltransferase 2A and officially known as KMT2A; herein referred to as MLL to denote the gene associated with mixed-lineage leukemia) generate MLL fusion proteins that bind DNA and drive leukemogenic gene expression. This gene expression program is dependent on the disruptor of telomeric silencing 1-like histone 3 lysine 79 (H3K79) methyltransferase DOT1L, and...
Topics
- Alleles
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Chromatin
- Epigenesis, Genetic
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Leukemic