Article

In vivo evidence for bleb-induced survival signaling in metastatic melanoma

2026-01-05

Abstract excerpt

Bleb signaling is a cellular process in which pressure-driven plasma membrane protrusions generate localized micron-scale membrane curvature that recruits cytosolic septin complexes, assembling signaling hubs that promote cell survival. Our prior work showed that this morphology-encoded signaling pathway is necessary to sustain anchorage-independent survival of BRAF and NRAS mutant melanoma cells in vitro. However...

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Literature Corpus work: 65451843-f9c5-532d-ac42-956ef5f85b2b
DOI: 10.64898/2026.01.05.697601

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