Article
Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth.
Oncotarget - 20 Feb 2015
Barsotti Anthony M, Ryskin Michael, Zhong Wenyan, Zhang Wei-Guo, Giannakou Andreas, Loreth Christine, Diesl Veronica, Follettie Maximillian, Golas Jonathon, Lee Michelle, Nichols Timothy, Fan Conglin, Li Gang, Dann Stephen, Fantin Valeria R, Arndt Kim, Verhelle Dominique, Rollins Robert A
Abstract excerpt
In addition to genetic alterations, cancer cells are characterized by myriad epigenetic changes. EZH2 is a histone methyltransferase that is over-expressed and mutated in cancer. The EZH2 gain-of-function (GOF) mutations first identified in lymphomas have recently been reported in melanoma (~2%) but remain uncharacterized. We expressed multiple EZH2 GOF mutations in the A375 metastatic skin melanoma cell line and...
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