Article

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination

2026-02-08

Abstract excerpt

Phenotypic plasticity is a prominent cancer feature that contributes to metastatic potential and resistance to therapy across multiple cancer types. Cancer cell state transitions have been attributed to transcriptional programs, such as the AP1/TEAD-regulated gene network driving the mesenchymal-like (MES) phenotype. In addition, during dissemination, tumor cells are subjected to variable loads of physical mechani...

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Identifiers and source

Literature Corpus work: e0007998-8455-58f1-a00d-0cb433fccf3b
DOI: 10.64898/2026.02.05.702638

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