Article

Serotonin Receptor Signaling Promotes Amoeboid Migration of Melanoma Cells Through cAMP/PKA Activation

2026-07-28

Abstract excerpt

Melanoma cells frequently utilize bleb-driven amoeboid migration to navigate confined microenvironments during metastasis. Through a morphology-based drug repurposing screen, we identified the anti-migraine medication dihydroergotamine (DHE) as a potent inhibitor of this behavior. We show that DHE suppresses amoeboid motility by targeting serotonin receptors, primarily 5-HTR7. Trace levels of peripheral serotonin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 846cf58b-bb4d-5396-915b-7f9fefc75d41
DOI: 10.64898/2026.07.27.741069

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Serotonin Receptor Signaling Promotes Amoeboid Migration of Melanoma Cells Through cAMP/PKA ActivationDOI 10.64898/2026.07.27.741069Read

5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation.Semantic proximity Read

TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and DisseminationSemantic proximity Read

MITF reprograms the extracellular matrix and focal adhesion in melanomaSemantic proximity Read

MITF reprograms the extracellular matrix and focal adhesion in melanomaSemantic proximity Read

In vivo evidence for bleb-induced survival signaling in metastatic melanomaSemantic proximity Read

The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAFV600E.Semantic proximity Read

Harnessing the polyamine transport system to treat BRAF inhibitor-resistant melanoma.Semantic proximity Read

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.Semantic proximity Read

The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.Semantic proximity Read

Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endotheliumSemantic proximity Read

Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signalingSemantic proximity Read

Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF ActivationSemantic proximity Read