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Article

The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis

6 Nov 2018

Abstract excerpt

The importance of studying cancer cell invasion is highlighted by the fact that 90% of all cancer-related mortalities are due to metastatic disease. Melanoma metastasis is driven fundamentally by aberrant cell motility within three-dimensional or confined environments. Within this realm of cell motility, cytokines, growth factors, and their receptors are crucial for engaging signaling pathways, which both mediate...

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PMID: 30460237
DOI: 10.3389/fmed.2018.00307

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