Article
Blebs promote cell survival by assembling oncogenic signalling hubs.
Nature - 1 Mar 2023
Weems Andrew D, Welf Erik S, Driscoll Meghan K, Zhou Felix Y, Mazloom-Farsibaf Hanieh, Chang Bo-Jui, Murali Vasanth S, Gihana Gabriel M, Weiss Byron G, Chi Joseph, Rajendran Divya, Dean Kevin M, Fiolka Reto, Danuser Gaudenz
Abstract excerpt
Most human cells require anchorage for survival. Cell-substrate adhesion activates diverse signalling pathways, without which cells undergo anoikis-a form of programmed cell death1. Acquisition of anoikis resistance is a pivotal step in cancer disease progression, as metastasizing cells often lose firm attachment to surrounding tissue2,3. In these poorly attached states, cells adopt rounded morphologies and form...
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