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Article

Melanoma topology reveals a stem-like phenotype that promotes angiogenesis.

Science advances - 1 Oct 2017

Lee Junmin, Abdeen Amr A, Hedhli Jamila, Wycislo Kathryn L, Dobrucka Iwona T, Fan Timothy M, Dobrucki Lawrence W, Kilian Kristopher A

Abstract excerpt

Tumor angiogenesis provides critical nutrients for cancer progression and may also facilitate pathways for dissemination during the process of metastasis. It is well established that cells that metastasize display characteristics of stem cells; however, the prevailing paradigm points to these stem-like cells residing in the hypoxic niche within the tumor interior. Controlling the geometry at the interface of a...

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Source

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Identifiers

PMID: 29075670
DOI: 10.1126/sciadv.1701350
PMCID: PMC5656422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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