Article

Blebs Promote Cell Survival by Assembling Oncogenic Signaling Hubs

2021-04-24

Abstract excerpt

Most human cells require anchorage for survival. Cell-substrate adhesion activates diverse signaling pathways, without which cells undergo anoikis – a form of programmed cell death 1 . Acquisition of anoikis resistance is a pivotal step in cancer disease progression, as metastasizing cancer cells often lose firm attachment to surrounding tissue 2–5 . In these poorly attached states, cells adopt rounded morpholog...

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Literature Corpus work: 392db4ea-efea-5762-bf1c-6a86628caf4a
DOI: 10.1101/2021.04.23.441200

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