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TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination

1 Nov 2015

Abstract excerpt

Cell migration underlies metastatic dissemination of cancer cells, and fast "amoeboid" migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated by extracellular signals and sustained over time by transcriptional changes is not fully understood. Transforming growth factor β (TGF-β) is well known to promote epithelial-to-mesenchymal...

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PMID: 26526369
DOI: 10.1016/j.cub.2015.09.054

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