Article

Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium

2020-03-20

Abstract excerpt

<h4>SUMMARY</h4> Uveal melanomas (UM) are malignant cancers arising from the pigmented layers of the eye. UM cells spread through the bloodstream, and circulating UM cells are detectable in patients before metastases appear. Extravasation of UM cells, notably transendothelial migration (TEM), is a key step in formation of metastases. UM cells execute TEM via a stepwise process of intercalation into the endothelia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed204e1d-d828-58b5-b52f-1cd08d3d3fb2
DOI: 10.1101/2020.03.18.997627

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endotheliumDOI 10.1101/2020.03.18.997627Read

Primordial Vasculogenic Mimicry Formation in Uveal MelanomaSemantic proximity Read

RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.Semantic proximity Read

Targeting Oncogenic Gαq/11 in Uveal MelanomaSemantic proximity Read

Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanomaSemantic proximity Read

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.Semantic proximity Read

In vivo evidence for bleb-induced survival signaling in metastatic melanomaSemantic proximity Read

ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma ProgressionSemantic proximity Read

Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels.Semantic proximity Read

Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodiaSemantic proximity Read

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression.Semantic proximity Read

Uveal melanoma cell lines Mel270 and 92.1 exhibit a mesenchymal phenotype and sensitivity to the cytostatic effects of transforming growth factor beta in vitro.Semantic proximity Read

Oncogenic GNAQ/11-induced remodeling of the IP3/Calcium signaling pathway protects Uveal Melanoma against Calcium-driven cell deathSemantic proximity Read