Article

Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein

2021-11-04

Abstract excerpt

Degrons are short stretches of amino acids or structural motifs that are embedded in proteins. They mediate recognition by E3 ubiquitin-protein ligases and thus confer protein degradation via the ubiquitin-proteasome system. Well-described degrons include the N-degrons, destruction boxes, and the PIP degrons, which mediate the controlled degradation of various proteins including signaling components and cell cycle...

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Literature Corpus work: 65172d9a-881e-5725-ab73-d19aab653bf0
DOI: 10.1101/2021.11.04.467226

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