Article
Disease-linked mutations cause exposure of a protein quality control degron.
Structure (London, England : 1993) - 1 Sept 2022
Kampmeyer Caroline, Larsen-Ledet Sven, Wagnkilde Morten Rose, Michelsen Mathias, Iversen Henriette K M, Nielsen Sofie V, Lindemose Søren, Caregnato Alberto, Ravid Tommer, Stein Amelie, Teilum Kaare, Lindorff-Larsen Kresten, Hartmann-Petersen Rasmus
Abstract excerpt
More than half of disease-causing missense variants are thought to lead to protein degradation, but the molecular mechanism of how these variants are recognized by the cell remains enigmatic. Degrons are stretches of amino acids that help mediate recognition by E3 ligases and thus confer protein degradation via the ubiquitin-proteasome system. While degrons that mediate controlled degradation of, for example,...
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