Article

How mutations of intrinsically disordered protein regions can drive cancer

2020-04-30

Abstract excerpt

Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation. IDRs are increasingly recognized as critical elements of regulatory networks and have been also associated with cancer. However, it is unknown whether mutations targeting IDRs represent a distinct class of driver events associated with specific molecular and syste...

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Literature Corpus work: be517ec3-5a23-52da-8c16-82159a2a2078
DOI: 10.1101/2020.04.29.069245

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