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Article

DegronMD: Leveraging Evolutionary and Structural Features for Deciphering Protein-Targeted Degradation, Mutations, and Drug Response to Degrons.

Molecular biology and evolution - 1 Dec 2023

Xu Haodong, Hu Ruifeng, Zhao Zhongming

Abstract excerpt

Protein-targeted degradation is an emerging and promising therapeutic approach. The specificity of degradation and the maintenance of cellular homeostasis are determined by the interactions between E3 ubiquitin ligase and degradation signals, known as degrons. The human genome encodes over 600 E3 ligases; however, only a small number of targeted degron instances have been identified so far. In this study, we...

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PMID: 37992195
DOI: 10.1093/molbev/msad253
PMCID: PMC10701100

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