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Article

A 'distributed degron' allows regulated entry into the ER degradation pathway.

The EMBO journal - 1 Nov 1999

Gardner R G, Hampton R Y

Abstract excerpt

Protein degradation is employed in both regulation and quality control. Regulated degradation of specific proteins is often mediated by discrete regions of primary sequence known as degrons, whereas protein quality control involves recognition of structural features common to damaged or misfolded proteins, rather than specific features of an individual protein. The yeast HMG-CoA reductase isozyme Hmg2p undergoes...

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Identifiers

PMID: 10545111
DOI: 10.1093/emboj/18.21.5994
PMCID: PMC1171665

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Source receipt: pubmed, retrieved 7 Sept 2026.

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