Article

A complete map of human cytosolic degrons and their relevance for disease

2025-05-15

Abstract excerpt

Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins from the intracellular space. Here, we describe a systematic screen for degrons in the human cytosol. We determine degron potency of >200,000 different 30-residue tiles from more than 5,000 cytosolic human proteins with...

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Literature Corpus work: cea848f8-aa33-5324-977a-b893afd58a34
DOI: 10.1101/2025.05.10.653233

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