Article

A compact, portable degron tool derived from the 3′UTR of <i>MTCH2</i> for tunable degradation of proteins

2026-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Targeted protein degradation relies on short sequence elements, termed degrons, that direct proteins to the cellular degradation machinery. Here, we report a nine-amino-acid degron (FYTVWRAFL) derived from the 3′ untranslated region (UTR) of human MTCH2 and demonstrate its utility as a tuneable protein-degradation tool. When appended to the C-terminus of proteins, FYTVWRAFL induces rapid and ro...

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Literature Corpus work: 092dccaf-5e28-5496-a1b2-0235e026d7ba
DOI: 10.64898/2026.02.04.703731

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