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Article

Characterization of intrinsically disordered regions in proteins informed by human genetic diversity.

PLoS computational biology - 1 Mar 2022

Ahmed Shehab S, Rifat Zaara T, Lohia Ruchi, Campbell Arthur J, Dunker A Keith, Rahman M Sohel, Iqbal Sumaiya

Abstract excerpt

All proteomes contain both proteins and polypeptide segments that don't form a defined three-dimensional structure yet are biologically active-called intrinsically disordered proteins and regions (IDPs and IDRs). Most of these IDPs/IDRs lack useful functional annotation limiting our understanding of their importance for organism fitness. Here we characterized IDRs using protein sequence annotations of functional...

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Identifiers

PMID: 35275927
DOI: 10.1371/journal.pcbi.1009911
PMCID: PMC8942211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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