Article

BAG6 and RNF126 promote the degradation of cytosolic misfolded proteins that contain buried degron motifs

2026-04-25

Abstract excerpt

Missense mutations account for the majority of catalogued human disease-associated variants, and many are predicted to destabilize proteins and promote their degradation. To characterize the pathways responsible for recognizing and clearing such variants, we employed a two-pronged approach to identify both quality control components mediating turnover of misfolded proteins and the sequence elements within their su...

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Literature Corpus work: eb5953a6-11de-5e1e-9d1a-33b944f47837
DOI: 10.64898/2026.04.24.720685

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