Article

Blocking protein quality control degradation leads to structural stabilization of DHFR indel variants

2025-12-11

Abstract excerpt

Gene variants leading to insertions or deletions of amino acid residues (indels) often have detrimental consequences for the folding of the encoded protein. Yet at some positions indels are tolerated or result merely in partial unfolding and hypomorphic phenotypes. Typically unfolded proteins are targeted for protein quality control (PQC) degradation via the ubiquitin-proteasome system, which in yeast is mediated...

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Literature Corpus work: 9aed685c-fe7e-5126-acfc-33bd85727d37
DOI: 10.64898/2025.12.09.693117

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