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Pharmacogenomic architecture of antihypertensive switching implicates neurotensin-NTSR1 signaling in ACE inhibitor-induced cough

2026-01-26

Abstract excerpt

Early failure of antihypertensive medication treatment affects one in four patients, but the underlying mechanisms are poorly understood. We aimed to identify genetic determinants of antihypertensive treatment failure within the first year. Using longitudinal medication data from >400,000 genotyped antihypertensive medication users across 3 cohorts (FinnGen, the UK Biobank, and the Estonian Biobank), we classified...

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Literature Corpus work
65085b56-46cc-5974-ad93-79ab0acc7a9f
DOI
10.64898/2026.01.26.26344813
Open publication

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Pharmacogenomic architecture of antihypertensive switching implicates neurotensin-NTSR1 signaling in ACE inhibitor-induced coughDOI 10.64898/2026.01.26.26344813
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