Article

Hidden Bias: GPCR Polymorphisms and the Genomic Landscape of β-Arrestin Signaling

2025-06-06

Abstract excerpt

Clinically, no human diseases are currently diagnosed as being directly driven by β- arrestins. Nonetheless, there is growing interest in developing β-arrestin–biased drugs, due to the key regulatory role of β-arrestins in modulating the cellular signaling of most G protein–coupled receptors (GPCRs). In cell-based studies of rhodopsin-family GPCRs, mutations in a conserved proline–hydrophobic (ProH) motif within t...

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Literature Corpus work: c1e4941a-3a42-566b-82b6-b0521cb152cf
DOI: 10.1101/2025.06.03.657708

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