Article
Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2013
Turner Stephen T, Boerwinkle Eric, O'Connell Jeffrey R, Bailey Kent R, Gong Yan, Chapman Arlene B, McDonough Caitrin W, Beitelshees Amber L, Schwartz Gary L, Gums John G, Padmanabhan Sandosh, Hiltunen Timo P, Citterio Lorena, Donner Kati M, Hedner Thomas, Lanzani Chiara, Melander Olle, Saarela Janna, Ripatti Samuli, Wahlstrand Björn, Manunta Paolo, Kontula Kimmo, Dominiczak Anna F, Cooper-DeHoff Rhonda M, Johnson Julie A
Abstract excerpt
To identify novel genes influencing blood pressure response to thiazide diuretic therapy for hypertension, we conducted genome-wide association meta-analyses of ≈1.1 million single-nucleotide polymorphisms in a combined sample of 424 European Americans with primary hypertension treated with hydrochlorothiazide from the Pharmacogenomic Evaluation of Antihypertensive Responses study (n=228) and the Genetic...
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