Article
Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry.
The pharmacogenomics journal - 1 Feb 2019
Irvin Marguerite R, Sitlani Colleen M, Noordam Raymond, Avery Christie L, Bis Joshua C, Floyd James S, Li Jin, Limdi Nita A, Srinivasasainagendra Vinodh, Stewart James, de Mutsert Renée, Mook-Kanamori Dennis O, Lipovich Leonard, Kleinbrink Erica L, Smith Albert, Bartz Traci M, Whitsel Eric A, Uitterlinden Andre G, Wiggins Kerri L, Wilson James G, Zhi Degui, Stricker Bruno H, Rotter Jerome I, Arnett Donna K, Psaty Bruce M, Lange Leslie A
Abstract excerpt
We evaluated interactions of SNP-by-ACE-I/ARB and SNP-by-TD on serum potassium (K+) among users of antihypertensive treatments (anti-HTN). Our study included seven European-ancestry (EA) (N = 4835) and four African-ancestry (AA) cohorts (N = 2016). We performed race-stratified, fixed-effect, inverse-variance-weighted meta-analyses of 2.5 million SNP-by-drug interaction estimates; race-combined meta-analysis; and...
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