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Article

Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes.

Pharmacogenetics and genomics - 1 Sept 2011

Mas Sergi, Gassò Patricia, Alvarez Santiago, Ortiz Jacint, Sotoca Jose M, Francino Antonio, Carne Xavier, Lafuente Amalia

Abstract excerpt

BACKGROUND AND OBJECTIVE: Dry cough is the most common reason for stopping angiotensin-converting enzyme inhibitors (ACEi) therapy. The role of ACE in the metabolism of bradykinin has been proposed as a pathogenic mechanism. This study included a complete analysis of the variability of the genes involved in bradykinin metabolism (ACE and XPNPEP2) and bradykinin receptors (BDKRB2). We included two polymorphisms in...

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Share to Angiotensin-Converting Enzyme Inhibitors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glycosyltransferases

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Share to Peptidyl-Dipeptidase A

Share to Receptor, Bradykinin B2

Source

Identifiers

PMID: 21832968
DOI: 10.1097/FPC.0b013e328348c6db

Genes

ABO
ACE
BDKRB2
AGTR1
XPNPEP2

Provenance

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