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Article

Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci

25 Jun 2022

Abstract excerpt

AIMS: To search for sequence variants associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs). METHODS AND RESULTS: A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons who switched from an ACEi treatment to an angiotensin receptor blocker....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35751511
DOI: 10.1093/eurheartj/ehac322

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