Article
PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study.
Pharmacogenomics - 1 Jun 2020
Mu Guangyan, Xiang Qian, Zhang Zhuo, Liu Chengzhang, Zhang Hanxu, Liu Zhiyan, Pang Xiaocong, Jiang Jie, Xie Qiufen, Zhou Shuang, Wang Zining, Hu Kun, Wang Zhe, Jiang Shanqun, Qin Xianhui, Cui Yimin
Abstract excerpt
Aim: We aimed to identify genetic variants associated with ACE inhibitor (ACEI)-induced cough. Materials & methods: A nested case-control study was performed among hypertensive Chinese patients receiving enalapril-only therapy. Whole-exome sequencing and genome-wide association analysis were performed. Results: We identified that PNPT1 rs13015243 (odds ratio [OR]: 0.47; 95% CI: 0.34-0.66; p = 7.45 × 10-6), PNPT1...
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