Article
Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors.
Pharmacogenetics and genomics - 1 Mar 2017
Mahmoudpour Seyed H, Veluchamy Abirami, Siddiqui Moneeza K, Asselbergs Folkert W, Souverein Patrick C, de Keyser Catherine E, Hofman Albert, Lang Chim C, Doney Alexander S F, Stricker Bruno H, de Boer Anthonius, Maitland-van der Zee Anke H, Palmer Colin N A
Abstract excerpt
OBJECTIVES: To identify single nucleotide polymorphisms (SNPs) associated with switching from an angiotensin-converting enzyme (ACE)-inhibitor to an angiotensin receptor blocker. METHODS: Two cohorts of patients starting ACE-inhibitors were identified within the Rotterdam Study in the Netherlands and the Genetics of Diabetes Audit and Research in Tayside Scotland study in Scotland. Cases were intolerant patients...
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