Article

Network analysis reveals the molecular bases of statin pleiotropy that vary with genetic background

2022-07-18

Abstract excerpt

Many approved drugs are pleiotropic, for example statins, whose main cholesterol lowering activity is complemented by anticancer and pro-diabetogenic mechanisms involving poorly characterized genetic interaction networks. We investigated these using the Saccharomyces cerevisiae genetic model where most genetic interactions known are limited to the statin-sensitive S288C genetic background. We therefore broadened...

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Literature Corpus work: 64afe3fd-a6de-5003-ad96-af425cdcb9e3
DOI: 10.1101/2022.07.17.500365

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