Article
A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions.
BMC biology - 23 Dec 2015
Sameith Katrin, Amini Saman, Groot Koerkamp Marian J A, van Leenen Dik, Brok Mariel, Brabers Nathalie, Lijnzaad Philip, van Hooff Sander R, Benschop Joris J, Lenstra Tineke L, Apweiler Eva, van Wageningen Sake, Snel Berend, Holstege Frank C P, Kemmeren Patrick
Abstract excerpt
BACKGROUND: Genetic interactions, or non-additive effects between genes, play a crucial role in many cellular processes and disease. Which mechanisms underlie these genetic interactions has hardly been characterized. Understanding the molecular basis of genetic interactions is crucial in deciphering pathway organization and understanding the relationship between genotype, phenotype and disease. RESULTS: To...
Topics
- Epigenesis, Genetic
- Gene Expression Profiling
- Gene Library
- Gene Ontology
- Molecular Sequence Annotation
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors