Article
The genetic landscape of a cell.
Science (New York, N.Y.) - 22 Jan 2010
Costanzo Michael, Baryshnikova Anastasia, Bellay Jeremy, Kim Yungil, Spear Eric D, Sevier Carolyn S, Ding Huiming, Koh Judice L Y, Toufighi Kiana, Mostafavi Sara, Prinz Jeany, St Onge Robert P, VanderSluis Benjamin, Makhnevych Taras, Vizeacoumar Franco J, Alizadeh Solmaz, Bahr Sondra, Brost Renee L, Chen Yiqun, Cokol Murat, Deshpande Raamesh, Li Zhijian, Lin Zhen-Yuan, Liang Wendy, Marback Michaela, Paw Jadine, San Luis Bryan-Joseph, Shuteriqi Ermira, Tong Amy Hin Yan, van Dyk Nydia, Wallace Iain M, Whitney Joseph A, Weirauch Matthew T, Zhong Guoqing, Zhu Hongwei, Houry Walid A, Brudno Michael, Ragibizadeh Sasan, Papp Balázs, Pál Csaba, Roth Frederick P, Giaever Guri, Nislow Corey, Troyanskaya Olga G, Bussey Howard, Bader Gary D, Gingras Anne-Claude, Morris Quaid D, Kim Philip M, Kaiser Chris A, Myers Chad L, Andrews Brenda J, Boone Charles
Abstract excerpt
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together...
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