Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae.

Abstract excerpt

Using genome-wide information to understand holistically how cells function is a major challenge of the postgenomic era. Recent efforts to understand molecular pathway operation from a global perspective have lacked experimental data on phenotypic context, so insights concerning biologically relevant network characteristics of key genes or proteins have remained largely speculative. Here, we present a global...

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