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Article

A pleiotropic-epistatic entangelement model of drug response.

Drug discovery today - 1 Nov 2023

Wang Yu, Sang Mengmeng, Feng Li, Gragnoli Claudia, Griffin Christopher, Wu Rongling

Abstract excerpt

Because drug response is multifactorial, graph models are uniquely powerful for comprehending its genetic architecture. We deconstruct drug response into many different and interdependent sub-traits, with each sub-trait controlled by multiple genes that act and interact in a complicated manner. The outcome of drug response is the consequence of multileveled intertwined interactions between pleiotropic effects and...

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PMID: 37758020
DOI: 10.1016/j.drudis.2023.103790

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