Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.

doi:10.1016/j.cell.2006.06.040

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Article

Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.

Cell - 11 Aug 2006

Parsons Ainslie B, Lopez Andres, Givoni Inmar E, Williams David E, Gray Christopher A, Porter Justin, Chua Gordon, Sopko Richelle, Brost Renee L, Ho Cheuk-Hei, Wang Jiyi, Ketela Troy, Brenner Charles, Brill Julie A, Fernandez G Esteban, Lorenz Todd C, Payne Gregory S, Ishihara Satoru, Ohya Yoshikazu, Andrews Brenda, Hughes Timothy R, Frey Brendan J, Graham Todd R, Andersen Raymond J, Boone Charles

Abstract excerpt

Discovering target and off-target effects of specific compounds is critical to drug discovery and development. We generated a compendium of "chemical-genetic interaction" profiles by testing the collection of viable yeast haploid deletion mutants for hypersensitivity to 82 compounds and natural product extracts. To cluster compounds with a similar mode-of-action and to reveal insights into the cellular pathways...

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PMID: 16901791
DOI: 10.1016/j.cell.2006.06.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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