Article
Genetic interaction networks: toward an understanding of heritability.
Annual review of genomics and human genetics - 1 Jan 2013
Baryshnikova Anastasia, Costanzo Michael, Myers Chad L, Andrews Brenda, Boone Charles
Abstract excerpt
Understanding the relationship between the genotypes and phenotypes of individuals is key for identifying genetic variants responsible for disease and developing successful therapeutic strategies. Mapping the phenotypic effects of individual genetic variants and their combinations in human populations presents numerous practical and statistical challenges. However, model organisms, such as the budding yeast...
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