Article

Predicting Drug Synergy and Antagonism from Genetic Interaction Neighborhoods

2016-04-27

Abstract excerpt

Although drug combinations have proven efficacious in a variety of diseases, the design of such regimens often involves extensive experimental screening due to the myriad choice of drugs and doses. To address these challenges, we utilize the budding yeast Saccharomyces cerevisiae as a model organism to evaluate whether drug synergy or antagonism is mediated through genetic interactions between their target genes....

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Literature Corpus work: a8e100a2-db1c-5287-987d-41c3499adaec
DOI: 10.1101/050567

Open publication

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